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KMID : 0893320100250010069
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Journal of Environmental Toxicology
2010 Volume.25 No. 1 p.69 ~ p.77
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Effectiveness of Scirpi rhizoma Ethanol Extract on Skin Whitening Using in vitro Test
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Ko Ju-Young
Kim Young-Chul
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Abstract
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The purpose of this study is to evaluate the effectiveness of Scirpi rhizoma ethanol extract (SREE) on skin whitening using in vitro test. In the anti oxidative activities, it was found that SREE contains 38.9㎎/g of polyphenol and 74.5 ㎎/g of flavonoid in total. In the electron donating ability, SREE showed a dose-dependent response, showing a high antioxidative capacity of 86.1% at 1000 ppm. It was found that the maximum permissible level of SREE to Melan-a cells was over 200 ppm, showing a quite low toxicity of SREE against Melan-a cells. Both in the inhibitory measurement for tyrosinase activity and melanogenesis using Melan-a cells, SREE presented a dose-dependent response with excellent efficacy.
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KEYWORD
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Scirpi rhizome, polyphenolic compound, tyrosinase activity, Melan-a cell, melanin content
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