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KMID : 0893320100250030215
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Journal of Environmental Toxicology
2010 Volume.25 No. 3 p.215 ~ p.222
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Comparison of Distribution and Inflammatory Response by Diameter and Shape of Silver Nanoparticles
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Kim Soo-Nam
Roh Jin-Kyu
Kang Min-Sung
Han Young-Ah
Lee Byoung-Seok
Kim Young-Hun
Park Kwang-Sik
Choi Kyung-Hee
Park Eun-Jung
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Abstract
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The market size of engineered nanoparticles is rapidly increasing due to the fast application of nanotechnolo-gies into different industries and consumer products. The development of new technology and materials has improved human"s quality of life, but it also entails the possibility of exposure to new materials. In this study, we compared the distribution in the body by the inflow of silver nanoparticles having another diameter and shape at 1 h or 24 h after injection via the tail vein. And, we compared the cell composition and cytokine concentration in SAL fluid, and histopathological changes. As results, discharge of silver nanoparticles having small diameter and sphere shape was more rapid than that of big diameter or plate shape. It is estimated that the toxicity in liver and lung was proportional to accumulation level. The persistence of inflammation was also longer in mice treated with plate shape. Consequently, we suggest that the first choice of silver nanoparticles having small diameter and sphere shape in applying is desirable.
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KEYWORD
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Silver nanoparticles, Distribution, Inflammation, Cytokine, Toxicity
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