KMID : 0893420200210020032
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Journal of Veterinary Science 2020 Volume.21 No. 2 p.32 ~ p.32
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Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (Oryctolagus cuniculus)
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Sitovs Andrejs
Voiko Laura Kustovs Dmitrijs Kovalcuka Liga Bandere Dace Purvina Santa Giorgi Mario
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Abstract
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Levofloxacin pharmacokinetic profiles were evaluated in 6 healthy female rabbits after intravenous (I/V), intramuscular (I/M), or subcutaneous (S/C) administration routes at a single dose of 5 mg/kg in a 3 ¡¿ 3 cross-over study. Plasma levofloxacin concentrations were detected using a validated Ultra Performance Liquid Chromatography method with a fluorescence detector. Levofloxacin was quantifiable up to 10 h post-drug administration. Mean AUC0-last values of 9.03 ¡¾ 2.66, 9.07 ¡¾ 1.80, and 9.28 ¡¾ 1.56 mg/h*L were obtained via I/V, I/M, and S/C, respectively. Plasma clearance was 0.6 mL/g*h after I/V administration. Peak plasma concentrations using the I/M and S/C routes were 3.33 ¡¾ 0.39 and 2.91 ¡¾ 0.56 ¥ìg/mL. Bioavailability values, after extravascular administration were complete, - 105% ¡¾ 27% (I/M) and 118% ¡¾ 40% (S/C). Average extraction ratio of levofloxacin after I/V administration was 7%. Additionally, levofloxacin administration effects on tear production and osmolarity were evaluated. Tear osmolarity decreased within 48 h post-drug administration. All 3 levofloxacin administration routes produced similar pharmacokinetic profiles. The studied dose is unlikely to be effective in rabbits; however, it was calculated that a daily dose of 29 mg/kg appears effective for I/V administration for pathogens with MIC < 0.5 ¥ìg/mL.
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KEYWORD
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Levofloxacin, rabbits, pharmacokinetics, tears, osmolar concentration
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