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KMID : 0895820080180020081
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Journal of Oriental Rehabilitation Medicine
2008 Volume.18 No. 2 p.81 ~ p.96
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The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet
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Kim Hyo-Young
Heo Dong-Seok
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Abstract
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Objectives :This study was performed to investigate inhibitory effects of Gamipalmul-tang(jiaweibawu-tang) on the hematological and histological changes of obese mice.
Methods :C57BL/6 mice were divided into four groups (normal group, high fat diet with normal saline, high fat diet with reductil, high fat diet with Gamipalmul-tang(jiaweibawu-tang)) and fed for 8 weeks. Body weight change, final increase of body weight, ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, cell viability by cytotoxicity, the expression of β3AR in 3T3-L1 cell, the expression of leptin, β3AR and serotonin in adipocyte tissue and size of adipocyte were observed in 8 weeks.
Results :1. In 3T3-L1 cell. the expression of β3AR was increased significantly. 2. The final increase of body weight in obese-mouse were decreased significantly. 3. The level of AST, ALT were decreased significantly. 4. The level of LDL-cholesterol was decreased significantly and HDL-cholesterol was increased significantly. 5. The levels of triglyceride was decreased and leptin and glucose were decreased significantly. 6. In adipocyte tissue, the expression of β3AR were increased significantly. 7 In adipocyte tissue, the expression of leptin and serotonin were decreased significantly. 8. The size of Adipocyte was decreased.
Conclusion :On the basis of these results, we concluded that Gamipalmul-tang(jiaweibawu-tang) has inhibitory effects in rat. 3
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KEYWORD
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Gamipalmul-tang(jiaweibawu-tang), Obesity, Body wight, Aiypocyte
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