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This study was designed to investigate effects on the morphology and the osmotic fragility of the methanethiol-treated of rats. The 7.5㎎ methanethiol was given to each rat per 100g body weight, and after 72hrs, the animals were sacrified. The apply of 0.02㎖ of rats whole blood to the 0.30% of NaCl solution showed complete hemolysis, but control groups showed complete hemolysis at the 0.15% of NaCl solution. The RBC count, hemoglobin, hematocrit, and MCH, and spleen weight per body weight of the methanethiol-treated rats were increased than those in the control groups, but the MCV was decreased. The WBC count and differential count of the methanethiol-treated rats were re decresed than those in the control groups, but the number of neutrophil was increased than those of the control groups. The spleen weight per body weight in methanethiol-treated rats were more increesed than those in the control group. These results suggest that the methanethiol may incluced the damage of rat’s spleen and caused by increased destruction of erythrocytes.
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