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Nasal polyposis is a common chronic disease of the nasal or paranasal sinus mucosa, with inflammatory cell infiltration and structural modifications of the epithelium and lamina propria. They are rounded projections of edematous mucous membrane that arise from the paranasal sinus cavities, causing very disabling symptoms and requiring longterm treatment with corticosteroids or even surgery. Their histopathology typically consists of an overlying intact respiratory epithelium with the underlying edematous or myxomatous stroma, showing various degrees of tissue remodeling in epithelium, glands, connective tissue and vessels. Although numerous papers have recently dealt with the pathogenesis of this nasal disease, the etiology and pathogenesis of nasal polyp are still controversial, and further investigation is needed. The present review is an update on the pathomechanisms of nasal polyposis.
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