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KMID : 0900920030270040333
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Korean journal of Animal Reproduction
2003 Volume.27 No. 4 p.333 ~ p.338
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Growth Rates of Transgenic Mice Containing Growth Hormone Receptor Gene
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Kim H.-J.
Naruse Kenji
Chang S.-M.
Im K.-S.
Lee S.-H.
Park C.-S.
Jin D.-I.
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Abstract
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Transgenic mice containing GH Receptor (GHR) gene fused to metallothionein promoter were analyzed to evaluate effect of GHR expression on growth in vivo. Three founder mice lines contained copies of GHR transgene and transmitted these genes into F_1 and F_2 progenies. The mRNA expression of transgene was identified using RT-PCR with GHR genes in tissues. To analyze the effects of transgenes on growth performance, body weights of pups were measured at 4, 10 and 14 weeks after birth. The body weight of transgenic mice was higher compared with that of non-transgenic control mice regardless of sex (P<0.05). Body weights between transgenic and non-transgenic mice were increased with aging. Overall, GHR transgenic mice tended to grow about 10 to 15 ％ faster than non-transgenic mice without any pathological defects.
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KEYWORD
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Transgenic mice containing GH receptor(GHR)
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