KMID : 0903519950380010037
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology 1995 Volume.38 No. 1 p.37 ~ p.41
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Age - Dependent Progesterone Metabolism in the Rat Brain
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Abstract
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The effect of age on the metabolism of progesterone was studied in the rat brain. Metabolic activity was more active in minced tissues than total homogenates. The activity of progesterone 5¥á-reductase(s) was increased during postnatal periods(between 5 and 14 days after birth) and thereafter steadily decreased up to the one-fourth level of the fetus. When 5¥á-dihydroprogesterone was incubated with brain tissues of various ages, the change in the activity of 3¥á-hydroxysteroid oxidoreductase(3¥á-HSOR) was similar to that of 5¥á-reductase(s). These results suggest that the reduced formation of total 5¥á-reduced metabolites was due to the decreased activities of 5¥á-reductase(s) and 3¥á-HSOR. However the level of 3¥â-HSOR remained constant regardless of the age.
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