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KMID : 0927720100110040333
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Korean Clinical Diabetes
2010 Volume.11 No. 4 p.333 ~ p.336
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A Case of Severe Hyponatremia Induced by Duloxetine
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Lee Min-Young
Park Kyu-Tae
Kang Jun-Goo
Ryu Ohk-Hyun
Kim Chul-Sik
Lee Seong-Jin
Kim Hyeon-Kyu
Hong Eun-Gyoung
Kim Doo-Man
Yu Sung-Hoon
Ihm Sung-Hee
Yoo Jae-Myung
Choi Moon-Gi
Yoo Hyung-Joon
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Abstract
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Duloxetine is a balanced selective serotonin and norepinephrine reuptake inhibitor (SNRI) which was recently approved for treatment of painful diabetic peripheral neuropathy. Hyponatremia is a well-described adverse event of SSRIs and SNRI, although the exact mechanism is unknown. Hyponatremia related to these medications is believed to be caused by the syndrome of inappropriate antidiuretic hormone (SIADH) and is probably a rare event. We recently experienced severe hyponatremia in a 76-year-old diabetic patient who was taking duloxetine for painful diabetic peripheral neuropathy. We report a case of severe hyponatremia induced by duloxetine use and a review of the related literature.
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KEYWORD
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Diabetic neuropathy, Duloxetine, Hyponatremia, SIADH
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