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KMID : 0939920020340060436
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대한암학회지
2002 Volume.34 No. 6 p.436 ~ p.438
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ℓ-myc Polymorphism in Gastric Cancer, Lung Cancer, and Hepatocellular Carcinoma
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Joo Ho Chung/Min Su Park
Sae Bin Jung/Yeon Hee Park/Bong Seog Kim/Hyun Ju Park/Hee Jae Lee/Soon Ae Kim/Bong Keun Choe/Joo Ho Chung
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Abstract
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Purpose: This study was performed to see if a particular polymorphism in the l-myc, a nuclear oncogene at the 1p32 locus, might be associated with greater risk of gastric cancer, lung cancer and hepatocellular carcinomas (HCC) in Korean patients.
Materials and methods: Genomic DNA, derived from patients diagnosed with gastric cancer (n=57), lung cancer (n=39), HCC (n=35) and healthy individuals (n= 176), was examined. The l-myc polymorphism under study was visualized by PCR followed by EcoRI digestion.
Results: There was no significant difference in the distribution of the l-myc polymorphism genotypes and allele frequencies between the cancer patients and the controls.
Conclusion: The l-myc polymorphism does not appear to be indicative of elevated risk of cancers of the stomach, lung and HCC.
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KEYWORD
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Gastric neoplasm, Lung neoplasm, Hepatocellular carcinoma, ℓ-myc polymorphism,
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