|
KMID : 0939920160480041382
|
|
대한암학회지
2016 Volume.48 No. 4 p.1382 ~ p.1388
|
|
|
Clinicopathologic Features and Long-Term Outcomes of Elderly Breast Cancer Patients: Experiences at a Single Institution in Korea
|
|
Kim Hee-Kyung
Ham Jun-Soo
Byeon Seong-Gyu
Yoo Kwai-Han
Jung Ki-Sun
Song Haa-Na
Cho Jin-Hyun
Lee Ji-Yun
Lim Sung-Hee
Kim Hae-Su
Kim Ji-Yeon
Lee Jeong-Eon
Kim Seok-Won
Nam Seok-Jin
Lee Se-Kyung
Bae Soo-Youn
Ahn Jin-Seok
Im Young-Hyuck
Park Yeon-Hee
|
|
|
Abstract
|
|
|
Purpose : The purpose of this study was to assess the tumor characteristics and long-term clinical outcomes of adjuvant treatments after surgery with a curative aim for patients with breast cancer who are 65 years and older.
Materials and Methods : Patients with breast cancer who underwent curative surgery from 2000 to 2009 were analyzed (n=4,388). Tumor characteristics and survival outcome were compared by dividing the patients into two age groups (< 65 and ≥ 65 years old). The Kaplan-Meier method was used for comparison of survival rates by log-rank test, and a Cox regression model was used to examine the effect of variables.
Results : Among 4,388 patients with invasive breast cancer, 317 patients (7.2%) were 65 years or older and the median age of all patients was 47 years (range, 18 to 91 years). Tumor characteristics were similar between the two age groups, but the older patients were treated less often with adjuvant treatments. During a median follow-up period of 122 months, recurrence-free survival (RFS) was equivalent for patients 65 years and older compared to younger patients, but significantly worse in overall survival (OS) and breast cancer?specific survival (BCSS) (5-year OS, 94.3% vs. 90.5%; p < 0.001 and 5-year BCSS, 94.7% vs. 91.8%; p=0.031). In the multivariate model, age ≥ 65 years old was identified as an independent risk factor for OS and RFS.
Conclusion : Elderly breast cancer appeared to have worse outcomes with very low prevalence in Korea, despite similar tumor characteristics. More active adjuvant therapies would have a role for aggressive subtypes for fit, elderly patients.
|
|
|
KEYWORD
|
|
|
Breast neoplasms, Aged, Population characteristics, Treatment outcome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|