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KMID : 0948920160150010001
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Clinical Pain
2016 Volume.15 No. 1 p.1 ~ p.8
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Diagnosis and Management of Spondy-loarthritis
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Park Eun-Hye
Lee Eun-Young
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Abstract
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Spondyloarthritis (SpA) is a group of chronic inflammatory disorders that share common clinical features, such as inflammation of the sacroiliac joints and spinal structures, peripheral arthritis, enthesitis, and extraarticular manifestations such as uveitis. They share a common genetic predisposition, the HLA-B27 gene. Radiographic sacroiliitis has been considered a hallmark of ankylosing spondylitis (AS). However definite evidence of sacroiliitis on plain radiographs is not observed during the early stages of disease. The Assessment in SpondyloArthritis international Society (ASAS) international working group has proposed a new set of diagnostic criteria that could identify SpA before the structural changes. The optimal management of patients with AS requires a combination of non-pharmacological and pharmacological treatment modalities. The first line of pharmacologic treatment is a nonsteroidal antiinflammatory drug (NSAID), and anti-TNF (tumor necrosis factor) therapy should be started to patients with high disease activity despite conventional treatments. TNF inhibitors have markedly improved the therapeutic options for patients with active AS.
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KEYWORD
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Spondyloarthritis, Sacroiliitis, ASAS (Assessment of SpondyloArthritis international Society), NSAID, TNF inhibitors
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