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KMID : 0984920130150020095
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Journal of Skin Barrier Research
2013 Volume.15 No. 2 p.95 ~ p.96
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Topical Hesperidin Rejuvenates Aged Epidermal Function in Aged Murine Model
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Song Shunpeng
Peter M. Elias
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Abstract
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Aged skin is featured by compromised epidermal permeability barrier homeostasis. Improvement of epidermal permeability barrier in aged skin is quite a challenge. Previous study demonstrated that topical hesperidin improves epidermal permeability barrier homeostasis in young mice. However, whether topical applications of hesperidin benefit epidermal permeability barrier function is not known yet. In the present study, we assessed the influence of topical applications of hesperidin on epidermal permeability barrier function and its underlying mechanisms in aged murine model. 12-15 month old hairless mice were topically treated with either 2% hesperidin or 70% ethanol alone twice daily for 25 days. At the end of study, stratum corneum function was assessed with an MPA5 physiology monitor. And barrier recovery rates were determined at 2 and 4 hours after barrier disruption by repeated tape-stripping. Our results show that topical applications of hesperidin lowered basal skin surface pH and increased basal transepidermal water loss. However, barrier recovery was significantly accelerated by hesperidin. The improved barrier function correlated with up-regulation of barrier-related protein, lipid synthetic enzyme and their mRNA expression. Moreover, topical hesperidin also significantly increased expression of epidermal mRNAs for mBD3, NHE1 and sPLA2g2f. These results suggest that topical application of hesperidin could be useful for preventing skin aging and treating aged skin.
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