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Introduction Stratum corneum (SC) contained extracellular lipids and NMF (natural moisturizing factor) absorbing atmospheric water and dissolving in their own water of hydration, all of them are related to skin barrier function. NMF, a complex mixture of low-molecular-weight, water-soluble compounds first formed within the corneocytes by degradation of the histidine-rich protein known as filaggrin. Each maturation step leading to the formation of an effective moisture barrier.including corneocyte strengthening, lipid processing, and NMF generation.is influenced by the level of SC hydration. Also, dry skin is known as the characteristics of decreased lipid content and a delayed reconstitution of the epidermal barrier after skin irritation. Therefore, moisturization and improvement of barrier function are important role of cosmetics. In this study, overall skin improvement was evaluated with cosmetics containing isotonic water mimicked body fluids and component like amino acid, peptide, monosaccharides to strengthen skin barrier. Material& methods Twenty-one healthy females (average age: 30.62±3.77yrs.) participated in this study for a week. Subjects evaluated in the study after taking a rest under constant temperature and relative humidity conditions (22±2℃, 50±5%) for 20 minutes. Skin hydration (Corneometer® CM 825, C+K, Germany), translucency (Radioscan, Truesystem, Korea), skin roughness (PRIMOS® Premium, GFMesstechnik GmbH, Germany), brightness and (VISIA® CR, Canfield, USA) were evaluated before treatment, at 20 minutes, 1 day and 1 week after treatment of test product contained isotonic fluid on face. Also self-questionnaires were performed about efficacy and usability of the test product. All obtained data were analyzed statistical differences with ANOVA test. Results Compared to before treatment, skin hydration was significantly increased at 20 minutes and 1 week after treatment (p<0.05). Skin translucency by diffuse subsurface reflection was shown significantly increased in angles (20°, 40°, 50°, 60° and 70°) at 1 week after treatment (p<0.05), compared to before treatment. In analysis of skin texture by 3D imaging system, compared to before treatment, Rmax, Rz and Rp parameters were significantly decreased at 1 week after treatment (p<0.05). Mean of intensity value for brightness was significantly increased and standard deviation (SD) of intensity value for evenness was significantly decreased at all measurement point after treatment (p<0.05). Conclusion In conclusion, overall improvement on the skin was shown with body fluid mimicked-cosmetic application for a week. Factors related to skin barrier recovery results from the hydration increment, improving to smooth skin surface and transparency increment.
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