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KMID : 0985420230450040149
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Laboratory Medicine and Quality Assurance
2023 Volume.45 No. 4 p.149 ~ p.155
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Performance Evaluation of the Beckman Coulter DxH 900 Automated Hematology Analyzer
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Yu Shin-Ae
Lee Ja-Young
You Eun-Kyoung
Song Sae-Am
Lee Jeong-Nyeo
Jun Kyung-Ran
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Abstract
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Background: The Beckman Coulter DxH 900 hematology analyzer (Beckman Coulter Inc., USA) is based on the Coulter Principle and accurately counts and measures the size of cells by monitoring changes in the electrical resistance of cells in a conductive liquid. Monocyte distribution width (MDW) is a new parameter of the DxH 900 analyzer that assists in the early diagnosis of sepsis. We evaluated the analytical performance of the DxH 900 for all parameters, including MDW.
Methods: We evaluated the precision, linearity, and carryover-related performance of the DxH 900, and analyzed the correlation between the DxH 900 and XE-2100 (Sysmex Corp., Japan) analyzers for all parameters (except MDW).
Results: The DxH 900 demonstrated acceptable precision for measuring normal and abnormal high- and low-level quality controls. The MDW repeatability was good (coefficient of variation of 3.99%?6.68%). White blood cells, red blood cells, hemoglobin, and platelets exhibited excellent linearity at high and low ranges, and no carryover effect was seen. The results obtained from the DxH 900 and XE-2100 analyzers were highly correlated.
Conclusions: The parameters including MDW of the DxH 900 analyzer showed good analytical performance and reproducibility. The parameters correlated well with the existing model, XE-2100. Our study demonstrated that the DxH 900 is useful in routine laboratories.
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KEYWORD
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Hemoglobins, Monocyte distribution width, Performance evaluation, Automated hematology analyzer
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