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KMID : 1001920090450030157
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Journal of Korean Neurosurgical Society
2009 Volume.45 No. 3 p.157 ~ p.163
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Stereotactic Radiosurgery with the CyberKnife for Pituitary Adenomas
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Cho Chul-Bum
Park Hae-Kwan
Joo Won-Il
Chough Chung-Kee
Lee Kyung-Jin
Rha Hyoung-Kyun
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Abstract
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Objective : In recent years, CyberKnife has emerged as an important treatment modality in the management of pituitary adenomas. Treatment results after performing CyberKnife and the complications of this procedure are reviewed.
Methods : Twenty-six patients with pituitary adenomas received stereotactic radiosurgery with the CyberKnife (CKRS). The follow-up periods ranged from 7 months to 47 months (mean±SD : 30±12.7 months). The patients consisted of 17 with non-functioning adenomas, 3 with prolactinomas and 6 with acromegaly. The change in the tumor volume, visual acuity, hormonal function, and complications by this therapy were analyzed in each case.
Results : The tumor control rate was 92.3%. Hormonal function was improved in all of the 9 (100%) functioning adenomas. Hormonal normalization was observed in 4 of the 9 (44%) patients with a mean duration of 16 months. In two patients (7.6%), visual acuity worsened due to cystic enlargement of the tumor after CKRS. No other complications were observed.
Conclusion : CyberKnife is considered safe and effective in selected patients with pituitary adenomas. However, longer follow-up is required for a more complete assessment of late toxicity and treatment efficacy.
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KEYWORD
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CyberKnife, Pituitary adenoma
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