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KMID : 1001920110500020089
Journal of Korean Neurosurgical Society
2011 Volume.50 No. 2 p.89 ~ p.94
Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke
Park Young-Woo

Koh Eun-Jeong
Choi Ha-Young
Abstract
Objective : D-dimer is a breakdown product of fibrin mesh after factor XIII stabilization. Previously, many authors have demonstrated a relationship between D-dimer level and stroke progression or type. This study aimed to investigate the relationship between D-dimer level and stroke volume.

Methods : Between January 2008 and December 2009, we analyzed the D-dimer levels of 59 acute ischemic stroke patients in our neurosurgical department both upon admission and after seven days of initial treatment. Each patient¡¯s National Institute of Health Stroke Scale score, modified Rankin Scales score, Glasgow outcome score, and infarction volume were also evaluated.

Results : Mean D-dimer level at admission was 626.6 ¥ìg/L (range, 77-4,752 ¥ìg/L) and the mean level measured after seven days of treatment was 238.3 ¥ìg/L (range, 50-924 ¥ìg/L). Mean D-dimer level at admission was 215.3 ¥ìg/L in patients with focal infarctions, 385.7 ¥ìg/L in patients with multiple embolic infarctions, 566.2 ¥ìg/L in those with 1-19 cc infarctions, 668.8 ¥ìg/L in 20-49 cc infarctions, 702.5 ¥ìg/L in 50-199 cc infarctions, and 844.0 ¥ìg/L in >200 cc infarctions (p=0.044). On the 7th day of treatment, the D-dimer levels had fallen to 201.0 ¥ìg/L, 293.2 ¥ìg/L, 272.0 ¥ìg/L, 232.8 ¥ìg/L, 336.6 ¥ìg/L, and 180.0 ¥ìg/L, respectively (p=0.530).

Conclusion : Our study shows that D-dimer level has the positive correlation with infarction volume and can be use to predict infarction-volume.
KEYWORD
D-dimer, Acute ischemic stroke, Volume
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