KMID : 1001920220650060861
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Journal of Korean Neurosurgical Society 2022 Volume.65 No. 6 p.861 ~ p.867
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Preliminary Study on Natural Killer Cell Activity for Interferon-Gamma Production after Gamma Knife Radiosurgery for Brain Tumors
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Park Kawng-Woo
Jeong Sang-Soon Kim Jung-Hoon Chung Hyun-Tai Lee Eun-Jung Moon Hyo-Eun Park Kwang-Hyon Kim Jin-Wook Park Hye-Ran Lee Jae-Meen Lee Hye-Ja Kim Hye-Rim Cho Yong-Hwan Paek Sun-Ha
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Abstract
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Objective: High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer.
Methods: We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFN¥ã) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFN¥ã (NKA-IFN¥ã) levels and clinical parameters of patients who were treated with GKS for brain tumors.
Results: NKA-IFN¥ã levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFN¥ã level of zero except one patient. High NKA-IFN¥ã levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS.
Conclusion: The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.
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KEYWORD
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Natural killer cell, Interferon-gamma, Gamma Knife Radiosurgery
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