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KMID : 1001920240670030299
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Journal of Korean Neurosurgical Society
2024 Volume.67 No. 3 p.299 ~ p.307
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Clinical Features and Treatment of Pediatric Cerebral Cavernous Malformations
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Phi Ji-Hoon
Kim Seung-Ki
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Abstract
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Cerebral cavernous malformation (CCM) is a vascular anomaly commonly found in children and young adults. Common clinical presentations of pediatric patients with CCMs include headache, focal neurological deficits, and seizures. Approximately 40% of pediatric patients are asymptomatic. Understanding the natural history of CCM is crucial and hemorrhagic rates are higher in patients with an initial hemorrhagic presentation, whereas it is low in asymptomatic patients. There is a phenomenon known as temporal clustering in which a higher frequency of symptomatic hemorrhages occurs within a few years following the initial hemorrhagic event. Surgical resection remains the mainstay of treatment for pediatric CCMs. Excision of a hemosiderin-laden rim is controversial regarding its impact on epilepsy outcomes. Stereotactic radiosurgery is an alternative treatment, especially for deepseated CCMs, but its true efficacy needs to be verified in a clinical trial.
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KEYWORD
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Cerebral cavernous malformation, Child, Hemorrhage, Epilepsy, Surgery
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