KMID : 1007519950040040264
|
|
Food Science and Biotechnology 1995 Volume.4 No. 4 p.264 ~ p.267
|
|
Comutagenic Effect of Sodium Chloride in the Salmonella/Mammalian Microsome Assay
|
|
Park, Kun Young
Suh, Myung Ja/Kim, So Hee
|
|
Abstract
|
|
|
The mutagenic and comutagenic effects of sodium chloride (NaCl) were investigated in Salmonella/mammalian microsome assay system. The comutagenicity of NaCl on N-methyl-N¢¥-nitro-N-nitrosoguanidine (MNNG) along with the inhibiting effect of vitamin C on its comutagenicity was also studied. Whether the activating enzyme mixture (S9 mixture) was absent or present in the system, NaCl revealed a slight mutagenic effect in the Salmonella typhimurium TA100, which exhibits a base-pair substitution mutagen. But the mutagenic effect of NaCl was not shown in the test strain of TA98 that detects a frameshift mutagen, suggesting that NaCl can be a weak base-pair substitution mutagen. NaCl also exhibited enhancing effect of the mutagenicities induced by aflatoxin B©û(AFB©û) and MNNG. Its comutagenicity was remarkable especially on the direct mutagen of MNNG. As the concentrations of NaCl increased the comutagenic effect of NaCl for MNNG increased significantly (p<0.05). The revertant numbers were about 3 times when 15% of NaCl was added to the MNNG in the system compared to MNNG alone. However, vitamin C decreased the comutagenicity of the NaCl on the MNNG mediated mutagenicity.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|