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KMID : 1007520070160040584
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Food Science and Biotechnology
2007 Volume.16 No. 4 p.584 ~ p.589
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Lipid Metabolism in Rats Fed Acetaminophen with Coadministration of Adzuki Bean Extract
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Han Kyu-Ho
Lee Chi-Ho
Ohba Kiyoshi
Shimada Ken-ichiro
Sekikawa Mitsuo
Fukushima Michihiro
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Abstract
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The effect of water extract of adzuki beans on acetaminophen-altered lipid metabolism was examined in rats. Control group of rats was fed a basal diet, another group of rats was fed 0.5% acetaminophen (APAP group), and a third group of rats was fed 0.5% acetaminophen plus 5% adzuki bean extract (ABE group) for 4 weeks. Serum total and HDL cholesterol levels in the APAP group were significantly lower than those in the control and ABE groups. Hepatic cholesterol 7α-hydroxylase and fatty acid synthase mRNA levels in the APAP and ABE groups were significantly higher and lower than in the control group, respectively. Hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA level in the APAP group was significantly lower than in the control group, whereas that in the ABE group was significantly higher than in the APAP group. These results indicate that adzuki bean extract may improve the acetaminophen-altered serum lipid metabolism in rats.
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KEYWORD
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acetaminophen, adzuki bean extract, cholesterol, 3-hydroxy-3-methyl-glutaryl-coenzyme A, HMG-CoA, reductase mRNA
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