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KMID : 1007520070160061064
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Food Science and Biotechnology
2007 Volume.16 No. 6 p.1064 ~ p.1068
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Antigenotoxic Effect of Paecilomyces tenuipes Cultivated on Soybeans in a Rat Model of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis
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Park Eun-Ju
Jeon Kyung-Im
Park Nam-Sook
Jin Byung-Rae
Lee Sang-Mong
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Abstract
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We evaluated the effect of soybean dongchunghacho [SD, cultivated dongchunghacho fungus (Paecilomyces tenuipes) on soybeans] on dimethylhydrazine (DMH)-induced DNA damage and oxidative stress in male F344 rats. The animals were divided into 3 groups and fed a casein-based high-fat, low fiber diet without (DMH group) or with 13%(w/w) of soybean (DMH+S group), or SD (DMH+SD group). One week after beginning the diets, rats were treated weekly with DMH (30 mg/kg, s.c.) for 6 weeks; dietary treatments were continued for the entire experiment and endpoints measured at 9 weeks after the first DMH injection. SD supplementation reduced DMH-induced DNA damage in colon cells and reduced plasma lipid peroxidation. Thus, SD may have therapeutic potential for early-stage colon carcinogenesis.
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KEYWORD
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Paecilomyces tenuipes cultivated on soybean, 1.2-dimethylhydrazine, DMH, colon carcinogenesis, DNA damage, antioxidant system
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