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KMID : 1007520080170010188
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Food Science and Biotechnology
2008 Volume.17 No. 1 p.188 ~ p.190
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Sasa quelpaertensis Leaf Extracts Induce Apoptosis in Human Leukemia HL-60 Cells
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Jang Mi-Gyeong
Park Soo-Young
Lee Sun-Ryung
Choi Soo-Youn
Hwang Joon-HO
Ko Hee-Chul
Park Ji-Gweon
Chung Wan-Seok
Kim Se-Jae
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Abstract
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In east Asia, the leaves of various Sasa species have been used in folk medicine for centuries. The effects of the methanolic extract and its subsequent fractions derived from the leaves of Sasa quelpaertensis Nakai on cell proliferation in human leukemia HL-60 cells were evaluated. The ethyl acetate fraction of this extract (ESQL) significantly reduced cell viability in a dose-dependent manner (0-250 ㎍/mL). ESQL (IC50=24.8 ㎍/mL) exhibited growth inhibition comparable to the main constituent of green tea, epigallocatechin (IC50=26.2 ㎍/mL), which was used as a positive control. ESQL treatment induced apoptosis, which was confirmed by the presence of nuclear condensation and annexin V-staining. These results demonstrate that ESQL contains chemopreventive phytochemicals that may be useful in neutraceutical applications.
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KEYWORD
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apoptosis, bamboo grass, cytotoxicity, HL-60 cell, Sasa quelpaertensis
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