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KMID : 1007520080170030594
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Food Science and Biotechnology
2008 Volume.17 No. 3 p.594 ~ p.597
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Effects of Water Extract of Smoke-dried Skipjack Tuna on Memory in a Scopolamine-induced Amnesia Animal Model
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Lim Soon-Sung
Hwang In-Koo
Yoo Ki-Yeon
Kang Il-Jun
Shin Hyun-Kyung
Kim Sang-Moo
Won Moo-Ho
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Abstract
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Natural products have been used to treat many neurological illnesses such as Alzheimer`s disease. In the present study, the effects of the water extract of smoke-dried skipjack tuna (WSST), which is used as a traditional seasoning in Japan, as well as its fractions on acetylcholinesterase (AChE) inhibition in vitro and on memory in scopolamine-induced amnesia mice in vivo were evaluated. Bio-Rad P-2 gel permeation chromatography revealed the presence of 7 peaks and AChE significantly inhibited peak 3 and 5. When in vivo behavioral studies were conducted, a passive avoidance test revealed that treatment with 50 and 100 mg/kg WSST as well as with fraction 3 and 5 improved the loss in memory retention induced by scopolamine. These results suggest that skipjack tuna extract and its fractions improve memory deficits and that these substances are suitable for use in healthy foods designed to improve memory deficits induced by aging and Alzheimer`s disease.
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KEYWORD
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smoke-dried skipjack tuna, acetylcholinesterase inhibitor, memory, cognitive function, passive avoidance
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