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KMID : 1007520080170030613
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Food Science and Biotechnology
2008 Volume.17 No. 3 p.613 ~ p.622
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Cancer Chemopreventive Effects of Korean Seaweed Extracts
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Lee Saet-Byoul
Lee Joo-Young
Song Dae-Geun
Pan Cheol-Ho
Nho Chu-Won
Kim Min-Cheol
Lee Eun-Ha
Jung Sang-Hoon
Kim Hyung-Seop
Kim Yeong-Shik
Um Byung-Hun
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Abstract
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Cancer chemopreventive effects can be exerted through the induction of phase II detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflammatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Cutleria cylindrica exhibited the high chemoprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at 100 ?g/mL by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desmarestia ligulata, Desmarestia viridis, Dictyopteris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin E2 (PGE2) production in a dose-dependant manner in 5-20 ?g/mL. These seaweed extracts could be used as food materials for cancer chemoprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and PGE2 production.
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KEYWORD
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quinone reductase, chemoprevention index, detoxification enzyme, antioxidant response element, anti-inflammation
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