|
KMID : 1007520080170061341
|
|
Food Science and Biotechnology
2008 Volume.17 No. 6 p.1341 ~ p.1344
|
|
|
Antioxidant Effects of Elsholtzia splendens Extract on DMBA-induced Oxidative Stress in Mice
|
|
Choi Eun-Jeong
Kim Tae-Hee
Kim Gun-Hee
|
|
|
Abstract
|
|
|
|
The present study was conducted to investigate the effects of flowers ethanol extract of Elsholtzia splendens (ESE)on the antioxidant defence system in mice with 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress. The ESEwas pre-administered orally to 2 groups of mice at 10 and 50 mg/kg body weight (BW) for 5 weeks. Subsequently, mice withpretreatment of ESE received DMBA intragastrically at a dose of 34 mg/kg BW twice a week for 2 weeks. In DMBA alonegroup, biomarkers of oxidative stress (TBARS value, carbonyl content, and serum 8-OH-dG) were significantly increased.Also, the antioxidant enzymes were down-regulated. ESE significantly restored the TBARS value and carbonyl content atboth doses, while a decrease in the elevated serum 8-OH-dG content was observed only at the higher dose. The DMBA-induced decreases in catalase and superoxide dismutase (SOD) activities were restored to nearly control levels by ESE.Glutathione peroxidase (GSH-px) and glutathione reductase (GR) activities, as well as the reduced glutathione (GSH)/oxidized GSH (GSSG) ratio, were significantly affected by ESE at the higher dose. These results suggest that ESE possessesantioxidant activity, which plays a protective role against DMBA-induced oxidative stress.
|
|
|
KEYWORD
|
|
|
Elsholtzia splendens, 7, 12-dimethylbenz(a)anthracene (DMBA), antioxidant, oxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|