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KMID : 1007520090180051284
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Food Science and Biotechnology
2009 Volume.18 No. 5 p.1284 ~ p.1287
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Effect of Stilbenoids on TNF-α-induced Adipokine Secretion
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Ahn Ji-Yun
Lee Hyun-Jung
Kim Su-Na
Ha Tae-Youl
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Abstract
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Tumor necrosis factor (TNF)-α is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-α have been implicated in both the induction of atherogenic adipokines, such as plasminogen activator inhibitor (PAI)-1, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of transstilbene, piceatannol, rhaponticin, and piceid on the TNF-α-induced atherogenic changes of adipokines in 3T3-L1 cells. Exposure to TNF-α for 24 hr increased PAI-1 secretion and decreased adiponectin secretion. Among stilbenoids, piceatannol significantly inhibited the increased secretion of PAI-1 induced by TNF-α. Adiponectin secretion decreased by TNF-α was recovered after trans-stilbene and rhaponticin treatments. Our results showed that stilbenoids exerted different effects on TNF- α-induced changes in adipokines secretion in 3T3-L1 adipocytes according to their structural characteristics.
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KEYWORD
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stilbenoid, 3T3-L1 adipocyte, plasminogen activator inhibitor-1, adiponectin
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