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KMID : 1007520100190010239
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Food Science and Biotechnology
2010 Volume.19 No. 1 p.239 ~ p.242
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Effect of King Oyster Mushroom (Pleurotus eryngii) on Insulin Resistance and Dyslipidemia in db/db Mice
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Kim Jung-In
Kang Min-Jung
Im Ji-Eun
Seo Yeong-Ju
Lee Young-Min
Song Ji-Hyun
Lee Jai-Heon
Kim Mi-Eun
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Abstract
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The present study examined the effect of the king oyster mushroom (Pleurotus eryngii) on insulin resistance and dyslipidemia in db/db mice. Four-week-old db/db mice were fed an AIN-93G diet or a diet containing 5% king oyster mushroom for 7 weeks. The blood glycated hemoglobin and serum glucose levels in the mushroom group were significantly lower than the control group (p< 0.05). Dietary king oyster mushroom significantly reduced the homeostasis model assessment for insulin resistance (HOMA-IR), total cholesterol, and triglyceride, and increased high density lipoprotein (HDL)-cholesterol. These results indicate that king oyster mushroom improves insulin sensitivity and exerts anti-hyperglycemic and anti-hyperlipidemic effects in db/db mice.
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KEYWORD
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diabetes mellitus, dyslipidemia, hyperglycemia, insulin resistance, king oyster mushroom
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