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KMID : 1007520100190010271
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Food Science and Biotechnology
2010 Volume.19 No. 1 p.271 ~ p.274
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Phenolic Components from the Leaves of Panax ginseng and Their Effects on HL-60 Human Leukemia Cells
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Nguyen Huu Tung
Son Jeong-Hyun
Cho Kyoung-won
Kim Jeong-Ah
Hyun Jae-Hee
Kang Hee-Kyoung
Song Gyu-Yong
Park Chun-Jung
Kim Young-Ho
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Abstract
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This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.
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KEYWORD
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Panax ginseng, Araliaceae, flavonoid, cytotoxic activity, HL-60 cell, apoptosis
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