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KMID : 1007520140230030889
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Food Science and Biotechnology
2014 Volume.23 No. 3 p.889 ~ p.893
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Eleutheroside E, an Active Compound from Eleutherococcus senticosus, Regulates Adipogenesis in 3T3-L1 Cells
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Jung Chang-Hwa
Ahn Ji-Yun
Heo Seok-Hyun
Ha Tae-Youl
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Abstract
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In this study, we investigated the anti-adipogenic effects of Eleutherococcus senticosus and its active compounds in vitro to examine new functions. We first analyzed the active compounds in E. senticosus growing in Korea using HPLC and found that the concentration of eleutheroside B and E was higher in stems and roots than in other plant parts. There were no significant (p<0.05) differences in eleutheroside concentration between plant ages. Anti-adipogenic effects of E. senticosus on lipid accumulation in 3T3-L1 cells were examined. Extracts of stems and roots more effectively inhibited lipid accumulation in 3T3-L1 cells than extracts of other plant parts. Eleutheroside E was responsible for the pharmacological anti-adipogenic effects via regulation of the mTOR pathway. This is the first report of an anti-adipogenic effect of E. senticosus and the active compound eleutheroside E.
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KEYWORD
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Eleutherococcus senticosus, eleutheroside E, anti-adipogenic effect, mTOR
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