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KMID : 1007520140230051703
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Food Science and Biotechnology
2014 Volume.23 No. 5 p.1703 ~ p.1707
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Lipase Inhibition and Cholesterol-lowering Activities of Laccase-catalyzed Catechin Polymers
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Jeon So-Youn
Imm Jee-Young
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Abstract
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The effects of laccase-catalyzed catechin polymers on lipid and cholesterol absorption were investigated in vitro. Laccase-catalyzed polymerization of (+)-catechin significantly increased the capacity to inhibit pancreatic lipase. The catechin polymer fraction extracted using 20% ethanol showed the highest activity with an IC50 value of 85 μM. Catechin polymers showed a significantly greater inhibitory effect (p<0.05) against pancreatic cholesterol esterase than the catechin monomer in a dose dependent manner. The inhibitory effect of catechins on cholesterol incorporation into micelles increased in the order of catechin monomer
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KEYWORD
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catechin polymers, laccase, lipase, cholesterol esterase, micellar solubility
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