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KMID : 1007520150240051897
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Food Science and Biotechnology
2015 Volume.24 No. 5 p.1897 ~ p.1900
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α-Glucosidase Inhibitory Activities of Myricetin in Animal Models of Diabetes Mellitus
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Kang Soo-Jeong
Yoon Park Jung-Han
Choi Ha-Neul
Kim Jung-In
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Abstract
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The α-glucosidase inhibitory activity of myricetin in vivo was investigated. Streptozotocininduced diabetic rats were administered a starch solution (1 g/kg) with and without myricetin (100 mg/ kg) or acarbose (40 mg/kg) after an overnight fast. Myricetin and acarbose alleviated postprandial hyperglycemia conditions, compared with untreated rats. Consumption of 0.08% myricetin or 0.03% acarbose in the diet for 7 weeks significantly (p<0.05) reduced the serum fasting glucose, blood glycated hemoglobin, and maltase activities of the small intestine in db/db mice, compared with controls. Myricetin can be beneficial for control of hyperglycemia in diabetes mellitus partly via inhibition of the α-glucosidase activity.
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KEYWORD
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myricetin, α-glucosidase, glucose, glycated hemoglobin, db/db mouse
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