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KMID : 1007520160250041135
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Food Science and Biotechnology
2016 Volume.25 No. 4 p.1135 ~ p.1145
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Hypoglycemic Effects of Sesquiterpene Lactones from Byrsonima crassifolia
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Gutierrez Rosa Martha Perez
Ramirez Alethia Muniz
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Abstract
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The novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of Byrsonima crassifolia were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in vitro in RIN-5F cells against oxidative stress was investigated and TNF-α and IL-6 levels were measured. Both Byrsonina types reduced blood glucose, cholesterol, triglyceride, lipoprotein, and transaminase levels and increased HDL-cholesterol, antioxidant enzymes, and TBARS-reactive substance levels. Byrsoninas A and B both improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic β-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role.
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KEYWORD
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guaianolides, antidiabetic, hyperlipidemia, Byrsonima crassifolia
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