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KMID : 1007520170260020481
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Food Science and Biotechnology
2017 Volume.26 No. 2 p.481 ~ p.487
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Inhibitory effect of Zizania latifolia chloroform fraction on allergy-related mediator production in RBL-2H3 cells
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Lee Eun-Jung
Yu Mi-Hee
Garcia Coralia V.
Jhee Kwang-Hwan
Yang Seun-Ah
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Abstract
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Zizania latifolia exhibits anti-inflammatory and anti-allergic effects; however, the mechanisms behind these effects are unknown. Here the ethanol extract of Z. latifolia was partitioned using hexane, chloroform, ethyl acetate, butanol, and water. Subsequently, the anti-allergic effects of these fractions were evaluated in vitro. The results showed that the chloroform fraction of Z. latifolia inhibited the release of β-hexosaminidase and tumor necrosis factor (TNF-α) from RBL-2H3 cells stimulated with dinitrophenyl-bovine serum albumin (DNP-BSA). In addition, this fraction suppressed the expression of cyclooxygenase-2 (COX-2) and inhibited the activation of mitogen-activated protein kinases (MAPKs). The results obtained suggest that the chloroform fraction of Z. latifolia inhibited mast cell-mediated allergic inflammatory responses.
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KEYWORD
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Zizania latifolia, anti-allergic, RBL-2H3 cells, COX-2, MAPK
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