KMID : 1007520170260030847
|
|
Food Science and Biotechnology 2017 Volume.26 No. 3 p.847 ~ p.852
|
|
Antifungal activity of isothiocyanates extracted from horseradish (Armoracia rusticana) root against pathogenic dermal fungi
|
|
Choi Kyu-Duck
Kim Hee-Yeon Shin Il-Shik
|
|
Abstract
|
|
|
To develop natural antifungal agents against pathogenic dermal fungi, the antifungal activity of isothiocyanates (ITCs) extracted from horseradish (Armoracia rusticana) root was investigated. A paper disk diffusion assay showed that ITCs inhibited growth of the four pathogenic dermal fungi (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, and Epidermophyton floccosum) at 5000 ¥ìg/mL, as well as perfectly inhibited the growth of the fungi at 10,000 ¥ìg/mL in a concentration-dependent manner. The minimum inhibitory concentrations of ITCs against T. rubrum, T. mentagrophytes, M. canis, and E. floccosum were 200, 200, 100, and 100 ¥ìg/mL, respectively. The minimum fungicidal concentrations of ITCs against the four pathogenic dermal fungi were 200 ¥ìg/mL. These results strongly suggested that ITCs extracted from horseradish root can be a candidate of natural antifungal agents against pathogenic dermal fungi, even though further study is needed to investigate how to use ITCs in clinical therapy.
|
|
KEYWORD
|
|
Antifungal activity, Isothiocyanates, Dermatophytes, MIC, MFC
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|