KMID : 1007520190280030857
|
|
Food Science and Biotechnology 2019 Volume.28 No. 3 p.857 ~ p.864
|
|
The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats
|
|
Seok Pu-Reum
Oh Su-Jin Choi Jin-Woo Lim Cho-Rong Choi Jong-Ryeol Kim Jung-Hoan Shin Jae-Ho
|
|
Abstract
|
|
|
To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117?¡¾?21.0 s) and HBA (101?¡¾?20.9 s) groups compared to the MCAO group (161?¡¾?12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-¥á and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
|
|
KEYWORD
|
|
Middle cerebral artery occlusion, Brain ischemia, Gastrodia elata Blume, 4-Hydroxybenzyl alcohol, Rat
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|