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KMID : 1007520200290040539
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Food Science and Biotechnology
2020 Volume.29 No. 4 p.539 ~ p.548
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Anti-inflammatory and in vitro bone formation effects of Garcinia mangostana L. and propolis extracts
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Lim Yun-Kyong
Yoo So-Young
Jang Young-Yoon
Lee Byoung-Cheon
Lee Dae-Sung
Kook Joong-Ki
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Abstract
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The purpose of this study was to determine the anti-inflammatory and in vitro bone formation effects of Garcinia mangostana L. (mangosteen) and propolis extracts. Immortalized human gingival fibroblasts (hTERT-hNOF) cells were treated with Porphyromonas gingivalis KCOM 2804 lipopolysaccharide followed by treatment with mangosteen and propolis extract alone or in combination. Expression levels of inflammatory cytokines were evaluated by enzyme-linked immunosorbent assay. Effect of mangosteen and/or propolis extracts on mineralization of MG-63 cells was evaluated by alkaline phosphatase activity and alizarin red S staining. Group mangosteen extract complex 1:34 (1 μg/ml mangosteen extract and 34 μg/ml propolis extract) significantly reduced expression levels of IL-6, IL-8, and PGE2. It had higher than other groups in vitro bone formation effect on MG63 cells. These results suggest that mangosteen and propolis extract complex could be used in the prevention and treatment of periodontal disease.
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KEYWORD
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Garcinia mangostana L., Propolis, Anti-inflammatory, In vitro bone formation
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