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KMID : 1007520230320101435
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Food Science and Biotechnology
2023 Volume.32 No. 10 p.1435 ~ p.1444
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Enzyme-derived deer velvet extract activate the immune response in cyclophosphamide-induced immunosuppressive mice
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Baek Sin-Hwa
Park Cho-I
Hwang Yun-Gyeong
Jeon Hye-Jin
Kim Seong-Eun
Song Ae-Ri
Park Hyun-Je
Park Il-Bum
Kang Jong-Soo
Cha Joo-Young
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Abstract
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Deer velvet (DV) is an oriental traditional medicine used to treat various diseases. The present study examined the effect of flavourzyme-derived DV extract (YC-1101) on macrophages and an immunosuppressed mouse model. YC-1101 induced activation of macrophages as measured by nitric oxide production, cell proliferation, and cytokine release via concentration-dependent phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, and AKT, and nuclear translocation of p65 in macrophages. In addition, oral YC-1101 administration significantly increased splenocyte proliferation and natural killer cell activity in the immunosuppressed mouse model. Moreover, the levels of immune-related cytokines such as tumor necrotic factor-α, interferon-γ, and interleukin-2 were significantly increased by YC-1101 treatment comparable to the control group. Thus, these results suggest that YC-1101 is an efficient natural ingredient that has an immune-enhancing effect, and it might be a potential functional food for improving immunity.
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KEYWORD
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Deer velvet, Immune-enhancing effect, Functional food, Immunosuppressed mouse model, Natural killer cell activity
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