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KMID : 1009020170150010019
Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 1 p.19 ~ p.27
Teratogenicity of Antiepileptic Drugs
Guveli Betul Tekin

Rosti Rasim Ozgur
Guzeltas Alper
Tuna Elif Bahar
Atakli Dilek
Sencer Serra
Yekeler Ensar
Kayserili Hulya
Dirican Ahmet
Bebek Nerses
Baykan Betul
Gokyigit Aysen
Gurses Candan
Abstract
Objective: Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies.

Methods: This is a retrospective study of malformations in children born to mothers currently followed up by our outpatient clinics who used or discontinued AED during their pregnancy. Their children were then investigated using echocardiography, urinary ultrasound, cranial magnetic resonance image, and examined by geneticists and pediatric dentists.

Results: One hundred and seventeen children were included in the study. Ninety one of these children were exposed to AED during pregnancy. The most commonly used AED were valproic acid and carbamazepine in monotherapy. The percentage of major anomaly was 6.8% in all children. Dysmorphic features and dental anomalies were observed more in children exposed especially to valproic acid. There were 26 mothers with two and four mothers with three pregnancies from the same fathers. No correlation was found between the distribution of malformations in recurring pregnancies and AED usage.

Conclusion: Our study has the highest number of dysmorphism examined in literature, found in all the children exposed to valproic acid, which may account for the higher rate of facial dysmorphism and dental anomalies. On lower doses of valproic acid, major malformations are not seen, although the risk increases with polytherapy. Our data also indicate possible effects of genetic and environmental factors on malformations.
KEYWORD
Dysmorphic features, Dental anomalies, Congenital malformations, Antiepileptic drugs, Teratogenesis
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