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KMID : 1009020170150010068
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Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 1 p.68 ~ p.69
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Disulfiram Induced Psychosis
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Mohapatra Satyakam
Rath Nihar Ranjan
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Abstract
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Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It’s major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.
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KEYWORD
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Disulfiram, Psychosis, Side effect
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