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KMID : 1009020170150010070
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Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 1 p.70 ~ p.72
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Mania in Wolfram’s Disease: From Bedside to Bench
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Chatterjee Seshadri Sekhar
Mitra Sayantanava
Pal Sali Kumar
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Abstract
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Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.
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KEYWORD
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Wolfram syndrome, Bipolar Disorder, Comorbidity
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