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KMID : 1009020170150030292
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Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 3 p.292 ~ p.295
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Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan
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Milano Giulia
Natta Werner Maria
Bello Alfredo
Martelli Antonietta
Mattioli Francesca
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Abstract
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The serotonin syndrome is a serioius medical condition due due to an intensive stimulation of setonin receptors. It is a rare, but severe, consequence of interaction between serotomimetic agents. This is a report of a 70-year-old woman steadily in therapy with venlafaxine and rizatriptan for migraine and major depressive syndrome. She was admitted to neurology unit for decreased light reflex with miotic pupils, global hyperreflexia, tremor, anxiety, ataxia and incoordination. The patient was diagnosed as a probable case of serotonin syndrome due to a pharmacological interaction between venlafaxine and rizatriptan trigged by opioid intake. In this paper, the development of syntomatology, the clinical examination and the possible pharmacokinetics explanation were carefully discussed and analysed.
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KEYWORD
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Drug-drug interactions, Codeine, Serotonin syndrome, Prescription drug misuse, Migraine disorders, Major depressive disorder
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