KMID : 1009020210190040610
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Clinical Psychopharmacology and Neuroscience 2021 Volume.19 No. 4 p.610 ~ p.617
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Satisfaction Survey on Antipsychotic Formulations by Schizophrenia Patients in Japan
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Hatano Masakazu
Takeuchi Ippei Yamashita Kanade Morita Aoi Tozawa Kaori Sakakibara Takashi Hajitsu Genta Hanya Manako Yamada Shigeki Iwata Nakao Kamei Hiroyuki
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Abstract
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Objective: To identify factors affecting adherence to medication, a subjective questionnaire survey was administered to schizophrenia patients regarding the prescribed antipsychotic formulations.
Methods: We evaluated the patients¡¯ satisfaction and dissatisfaction with prescribed antipsychotic formulations, and patients answered the Drug Attitude Inventory-10 Questionnaire (DAI-10). Inclusion criteria for patients are as follows: age between 20 and 75 years and taking antipsychotic agents containing the same ingredients and formulations, for at least 1 month.
Results: In total, 301 patients answered the questionnaire survey. Tablets were found to be the most commonly used antipsychotic formulations among schizophrenia patients (n = 174, 57.8%), followed by long-acting injections (LAIs, n = 93, 30.9%). No significant differences in the formulation satisfaction level and DAI-10 scores were observed between all formulations. Formulations, except for LAI, were selected by physicians in more than half of the patients. Patients who answered ¡°Decided by consultation with physicians¡± had significantly higher satisfaction levels and DAI-10 scores compared to those who answered ¡°Decided by physicians¡± (4.11 ¡¾ 0.77 vs. 3.80 ¡¾ 1.00, p = 0.0073 and 6.20 ¡¾ 3.51 vs. 4.39 ¡¾ 4.56, p < 0.001, respectively). Satisfaction levels moderately correlated with DAI-10 scores (r = 0.48, p < 0.001).
Conclusion: No formulation had a high satisfaction level in all patients, and it is important to be reflect the patients¡¯ individual preferences in pharmacotherapy. Shared decision-making in the selection of the formulations is seen to be useful for improving medication adherence.
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KEYWORD
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Antipsychotic agents, Schizophrenia, Surveys and questionnaires, Patient satisfaction, Medication adherence, Drug formulation
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