KMID : 1009020240220010169
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Clinical Psychopharmacology and Neuroscience 2024 Volume.22 No. 1 p.169 ~ p.181
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Associations between Education Years and Resting-state Functional Connectivity Modulated by APOE ¥å4 Carrier Status in Cognitively Normal Older Adults
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Kim Ji-Won
Kim Sung-Hwan Um Yoo-Hyun Wang Sheng-Min Kim Regina EY Choe Yeong-Sim Lee Ji-Yeon Kim Dong-Hyeon Lim Hyun-Kook Lee Chang-Uk Kang Dong-Woo
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Abstract
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Objective: Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer¡¯s disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognitively preserved older adults differs depending on amyloid-beta deposition and APOE ¥å4 carrier status as effect modifiers.
Methods: A total of 121 participants underwent functional magnetic resonance imaging, [18F] flutemetamol positron emission tomography-computed tomography, APOE genotyping, and a neuropsychological battery. Potential interactions between years of education and AD risk factors for rFC of AD-vulnerable neural networks were assessed with whole-brain voxel-wise analysis.
Results: We found a significant education years-by-APOE ¥å4 carrier status interaction for the rFC from the seed region of the central executive (CEN) and dorsal attention networks. Moreover, there was a significant interaction of rFC between right superior occipital gyrus and the CEN seed region by APOE ¥å4 carrier status for memory performances and overall cognitive function.
Conclusion: In preclinical APOE ¥å4 carriers, higher years of education were associated with higher rFC of the AD vulnerable network, but this contributed to lower cognitive function. These results contribute to a deeper understanding of the impact of cognitive reserve on sensitive functional intermediate phenotypic markers in the preclinical phase of AD.
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KEYWORD
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Apolipoproteins E, fMRI, Education, Cognitive function, Aged
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