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KMID : 1011320220140010047
Journal of Pharmacoepidemiology and Risk Management
2022 Volume.14 No. 1 p.47 ~ p.50
An Overview of Multiple Drug Hypersensitivity Syndrome
Sohn Kyoung-Hee

Abstract
The multiple drug hypersensitivity syndrome (MDHS) is a novel condition characterized by a delayed hypersensitivity reaction to two structurally different drugs. It is important to be able to distinguish between MDHS and multiple drug intolerance and/or flare-up reactions. MDHS should thus be confirmed using delayed intradermal tests, patch tests or in vitro tests. Recent studies have reported that the initial reactions manifest most commonly as a drug reaction with eosinophilia and systemic symptoms (DRESS); fixed combination antibiotics such as sulfamethoxazole/trimethoprim or piperacillin/tazobactam are frequently involved in MDHS. The occurrence of MDHS depends on the status of previous T cell activations, and its immune response is similar to that seen in graft versus host disease and viral infections. The first drug hypersensitivity response lowers the T cell proliferation threshold for the drug and causes a rapid appearance of hypersensitivity symptoms to the second drug. Accurate diagnosis of MDHS is needed for its proper management.
KEYWORD
Multiple drug hypersensitivity, Drug reaction with eosinophilia and systemic symptoms (DRESS), Drug hypersensitivity
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