KMID : 1011720170100010050
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International Journal of Thyroidology 2017 Volume.10 No. 1 p.50 ~ p.55
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Sweet¡¯s Syndrome Associated with Graves¡¯ Disease
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Yong Ho-Jin
Kang Mi-Il Kim Do-Hee
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Abstract
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Sweet¡¯s syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto¡¯s thyroiditis but is rare in Graves¡¯ disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet¡¯s syndrome in a patient with Graves¡¯ disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves¡¯ disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet¡¯s syndrome, supporting that Sweet¡¯s syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet¡¯s syndrome associated with Graves¡¯ disease per se but not PTU or MMI use.
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KEYWORD
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Acute febrile neutrophilic dermatosis, Anti-thyroid drugs, Graves¡¯ disease, Hashimoto¡¯s thyroiditis, Sweet¡¯s syndrome
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