KMID : 1011720180110010041
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International Journal of Thyroidology 2018 Volume.11 No. 1 p.41 ~ p.48
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Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers
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Chae In-Hye
Kim Eun-Kyung Moon Hee-Jung Yoon Jung-Hyun Park Vivian Y. Lee Hye-Sun Moon Ji-Eun Kwak Jin-Young
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Abstract
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Background and Objectives: The present study investigated the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs).
Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis.
Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence.
Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.
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KEYWORD
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Lymphocyte, Lymph node metastasis, Neutrophil, Recurrence, Papillary thyroid carcinoma
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