|
KMID : 1022820220130020023
|
|
Journal of Multiple Sclerosis and Neuroimmunology
2022 Volume.13 No. 2 p.23 ~ p.29
|
|
|
Autoimmune Nodopathies
|
|
Lyou Hyun-Ji
Shin Ha-Young
|
|
|
Abstract
|
|
|
|
utoantibodies against proteins at the node of Ranvier such as neurofascin-155, contactin-1, contactin-associated protein-1, and neurofascin-140/186 have been discovered in a proportion of patients with peripheral neuropathy fulfilling the previous diagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (for example, European Federation of Neurological Societies and the Peripheral Nerve Society [EFNS/PNS] 2010 criteria). Although peripheral neuropathies with these autoantibodies can meet the criteria, they show distinct clinical characteristics, such as poor response to intravenous immunoglobulin and/ or corticosteroids and no macrophage-mediated demyelination or overt inflammation, which are not typical of CIDP. For these reasons, a new concept of “autoimmune nodopathy” has been proposed and distinguished from CIDP. This review briefly summarized the structure of the node of Ranvier and autoimmune nodopathies associated with autoantibodies against neurofascin-155, contactin-1, contactin-associated protein-1, and neurofascin-140/186.
|
|
|
KEYWORD
|
|
|
Chronic inflammatory demyelinating polyradiculoneuropathy, Ranvier’s nodes, Autoantibodies
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|