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KMID : 1023519900130010032
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Korean Journal of Veterinary Service
1990 Volume.13 No. 1 p.32 ~ p.43
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Immunohistochemical and Pathological Observations of the Rats Experimentally Infected with Aujeszky’s Disease Virus
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Cho Woo-Young
Cho Bu-Je
Cho Seong-Whan
Lee Chul-Ho
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Abstract
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In order to investigate the clinico-pathological and immunohistochemical changes in the rats infected with Aujeszky’s disease virus(ADV), 100 heads of 4 weeks-old rats were inoculated intraperitoneally and intranasally, with the domestically isolated ADV, NYJ-1-87 strain, at or /0.2ml. Results obtained through the experiments were summarized as follows : 1. Clinical signs such as dulness, anorexia, pruritus, fascial edema, dyspnea and ataxia were observed from the 2nd day and died at the 3rd to 5th day after ADV inoculation. By necropsy, congestion and hemorrhage were observed in the abdominal organs, while no specific changes were detected in the other organs. 2. In histopathological observation, degeneration and necrosis of the nervous cells, non-suppurative meningoencephalitis, microgliosis and perivascular cuffing were manifested in central nerve system but no specific changes were observed in the other organs. 3. By immunohistochemical staining using peroxidase antiperoxidase, the positive cells were detected in the tissues of kideny, spleen, urinary bladder and lung.
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KEYWORD
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Immunohistochemical and pathological observations rats, Aujeszky’s disease virus
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