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KMID : 1023519900130010054
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Korean Journal of Veterinary Service
1990 Volume.13 No. 1 p.54 ~ p.63
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Immune Responses in Swine and Experimental Animals Given Inactivated Aujeszky’s Disease Virus Antigens
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Park Jong-Woo
Lee Jong-In
Choi Yun-Sic
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Abstract
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We have studied about the safety, immunity and protective potency in swine and experimental am mais of two inactivated vaccine produced with NYJ-1-87 strain of ADV that was isolated in Korea. Result obtained through the experiments were summarized as follows. 1. The safe potency of ADV antigens inactivated with BEI and formaline to mouse & guinea pig was on the whole good, but protective potency rates of those to challenge with ADV were 60-75％ without the differences to two antigens. 2. Safety, immunity & protective potency of ADV antigens inactivated with BEI and formaline to swine were on the whole excellent, except for a mild increase of rectal temperature in some pigs after challenge with ADV. 3. When virus excretion of the experimental groups after challenge with ADV was examed by swabbing of nasal, all pigs of control gorup excreted virus from 2 days p.c., partially to 10 days p.c.. But in vaccinated groups, only 25-50% of all pigs of each group excreted virus during experimental periods. 4. Titers of antibodies in swine & quinea pig vaccinated with inactivated ADV antigens become increased after the 1 weeth p.i. showing the highest liters on the 4-5 weeths p.i.
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KEYWORD
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ADV NYJ-1-87 strain, inactivated vaccine, protective potency
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